Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
Embryonic Stem Cells00:58

Embryonic Stem Cells

32.7K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.7K
Embryonic Stem Cells00:57

Embryonic Stem Cells

5.2K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
5.2K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.1K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.1K
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

30.4K

Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.4K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

1.2K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: The BSSPD 2025 debate: sustainability of dentistry and prosthodontics - is this an emergency?

British dental journal·2026
Same author

The BSSPD 2025 debate: sustainability of dentistry and prosthodontics - is this an emergency?

British dental journal·2026
Same author

My mouth matters: A dental care professional led oral health programme to improve oral health and mouth care to residents of care homes in the East of England.

Community dental health·2026
Same author

Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment.

Nature communications·2026
Same author

AQP5: A functional gastric cancer stem cell marker in mouse and human tumors.

Science (New York, N.Y.)·2025
Same author

Hepatic zonation determines tumorigenic potential of mutant β-catenin.

Nature·2025

Related Experiment Video

Updated: Feb 14, 2026

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

14.0K

Recent Advances in Lgr5+ Stem Cell Research.

Carly Leung1, Si Hui Tan1, Nick Barker2

  • 1A*STAR Institute of Medical Biology, 138648, Singapore; These authors contributed equally.

Trends in Cell Biology
|February 26, 2018
PubMed
Summary

Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) marks adult stem cells and influences Wnt/R-spondin signaling. New models reveal Lgr5+ cells in regeneration, gut cancer stem cells, and lung niches, impacting stem cell therapy.

More Related Videos

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

1.9K
Reprogramming Human Somatic Cells into Induced Pluripotent Stem Cells iPSCs Using Retroviral Vector with GFP
08:25

Reprogramming Human Somatic Cells into Induced Pluripotent Stem Cells iPSCs Using Retroviral Vector with GFP

Published on: April 3, 2012

21.1K

Related Experiment Videos

Last Updated: Feb 14, 2026

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

14.0K
Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

1.9K
Reprogramming Human Somatic Cells into Induced Pluripotent Stem Cells iPSCs Using Retroviral Vector with GFP
08:25

Reprogramming Human Somatic Cells into Induced Pluripotent Stem Cells iPSCs Using Retroviral Vector with GFP

Published on: April 3, 2012

21.1K

Area of Science:

  • Stem Cell Biology
  • Molecular Signaling
  • Regenerative Medicine

Background:

  • Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) is identified as a key marker for adult stem cells.
  • Lgr5 plays a crucial role in Wnt/R-spondin signaling, modulating stem cell activity.
  • Understanding Lgr5 is vital for stem cell biology in homeostasis, regeneration, and disease.

Purpose of the Study:

  • To review recent advances in Lgr5 stem cell research.
  • To discuss the role of Lgr5-expressing cells in various physiological and pathological contexts.
  • To explore the therapeutic potential of adult stem cells and cancer stem cells.

Main Methods:

  • Utilized new mouse models to study endogenous Lgr5-expressing cell behavior.
  • Employed organoid culture systems to investigate Lgr5+ cell functions in vitro.
  • Reviewed existing literature on Lgr5's role in stem cell biology and disease.

Main Results:

  • Identified facultative stem cell populations crucial for tissue regeneration.
  • Revealed Lgr5-expressing cancer stem cells (CSCs) driving metastasis in the gut.
  • Discovered Lgr5+ niche cells in the lung with significant biological roles.

Conclusions:

  • Lgr5 is a pivotal marker and regulator of adult stem cell function.
  • Lgr5+ cells are implicated in tissue regeneration, cancer progression, and niche maintenance.
  • These findings have significant implications for developing novel stem cell-based therapies.