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Updated: Feb 14, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Angiogenic potential of YKL-40 in the dynamics of tumor niche
Ayda Pouyafar1, Milad Zadi Heydarabad2, Soltanali Mahboob1
1Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran.
Abstract:
A multitude of clinical studies showed the elevation of YKL-40 in subjects with different kinds of tumors. It is predicted that an inherent correlation exists between survivals of cancer patients with total YKL-40 serum levels, making this factor as a potential novel biomarker. However, the crucial role of YKL-40 in the dynamics of cancers, especially angiogenesis, has not yet been completely addressed. In this review, we highlighted the various facets of YKL-40 and its importance in cancer biology as a bio-shuttle in gene therapy.
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