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Related Concept Videos

Unusual Results01:16

Unusual Results

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Unusual results are those that have a very low chance of occurring. Unusual results can be identified using probabilities and the range rule of thumb. In problems involving probability, unusual results can be observed in 2 instances – an unusually high number of successes or an unusually low number of successes.
According to the range rule of thumb, any value above or below two standard deviations, 2σ  from the mean, μ  is considered unusual.
Maximum unusual value =...
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The Evidence for Evolution02:55

The Evidence for Evolution

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Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
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Convergent Evolution01:54

Convergent Evolution

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Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
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z Scores and Unusual Values01:07

z Scores and Unusual Values

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The z score is one of the three measures of relative standing. It describes the location of a value in a dataset relative to the mean. z scores are obtained after the standardization of the values in a dataset. The z score for the mean is 0.
 This score indicates how far a value is from the mean in terms of standard deviation. For example, if a data value has a z score of +1, the researcher can infer that the particular data value is one standard deviation above the mean. If another data...
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Eukaryotic Evolution01:24

Eukaryotic Evolution

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The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
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Synteny and Evolution02:31

Synteny and Evolution

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John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
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Updated: Feb 14, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
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Recurrent postinfectious glomerulonephritis: an unusual evolution compatible with C3 glomerulopathy.

Jose Luis Espinosa-Figueroa1, Marta Cano-Megías1, Patricia Martínez-Miguel1

  • 1Nephrology, Hospital Universitario Principe de Asturias, Alcala de Henares, Spain.

BMJ Case Reports
|February 26, 2018
PubMed
Summary

Acute endocapillary glomerulonephritis typically resolves quickly. However, this case highlights its potential to become chronic due to complement pathway deregulation, presenting with recurrent acute kidney injury.

Area of Science:

  • Nephrology
  • Immunology
  • Complement System

Background:

  • Acute endocapillary glomerulonephritis is usually a self-limiting condition.
Keywords:
acute renal failurehematuriaproteinurea

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  • A subset of patients develop chronic disease, potentially linked to complement pathway dysregulation.
  • The alternative complement pathway's role in chronic glomerulonephritis is an area of ongoing research.