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The Interactions of the Immune System and the Brain in Hypertension

Marialuisa Perrotta1, Giuseppe Lembo1,2, Daniela Carnevale3,4

  • 1Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, 86077, Pozzilli, IS, Italy.

Current Hypertension Reports
|February 26, 2018
PubMed

Insights

Hypertension remains a global health crisis, with many patients resistant to current treatments. Emerging research highlights the crucial interplay between the autonomic nervous system and immunity in blood pressure regulation.

Area of Science:

  • Cardiovascular Research
  • Neuroimmunology
  • Hypertension Pathophysiology

Background:

  • Hypertension affects millions globally, leading to significant mortality and disability.
  • Current antihypertensive therapies are insufficient for a substantial number of refractory patients.
  • Complex, multifactorial mechanisms underlie hypertension development and maintenance.

Purpose of the Study:

  • To review the emerging understanding of the interaction between the autonomic nervous system and immunity in hypertension.
  • To integrate this novel neuro-immune concept into existing models of blood pressure regulation.

Main Methods:

  • Literature review of recent contributions on neural modulation of immunity in hypertension.
  • Analysis of how autonomic nervous system regulation of immunity impacts blood pressure.

Main Results:

  • The autonomic nervous system significantly modulates immune responses relevant to hypertension.
  • This neural-immune axis represents a critical, previously underappreciated factor in blood pressure control.
  • Understanding these interactions is key to developing novel therapeutic strategies.

Conclusions:

  • The autonomic nervous system and immune system are intricately linked in the pathophysiology of hypertension.
  • Targeting the neuro-immune interface offers a promising avenue for treating resistant hypertension.
  • Further research into this complex interaction is warranted for improved patient outcomes.
Abstract

Keywords:
Autonomic nervous systemHypertensionImmune systemNeuroimmune reflexesSplenic nerve activityVagus nerve

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