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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

17.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

8.0K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
8.0K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Acute Myocardial Infarction in Rats
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Acute Myocardial Infarction in Rats

Published on: February 16, 2011

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Inflammatory Response During Myocardial Infarction.

Joaquim B Oliveira1, Alexandre A S M Soares1, Andrei C Sposito1

  • 1Laboratory of Atherosclerosis and Vascular Biology, State University of Campinas, Campinas, Brazil.

Advances in Clinical Chemistry
|February 27, 2018
PubMed
Summary

Myocardial infarction (MI) involves inflammation that can worsen heart damage. Regulating this inflammatory response is crucial for cardiac recovery and preventing further atherosclerosis progression.

Keywords:
AtherosclerosisInflammationMyocardial infarction

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Area of Science:

  • Cardiovascular Research
  • Immunology
  • Pathophysiology

Background:

  • Myocardial infarction (MI) is often caused by atherosclerotic plaque rupture and thrombus formation.
  • The resulting cell death triggers an inflammatory response that can exacerbate cardiac damage and affect prognosis.
  • Excessive or dysregulated inflammation post-MI is a significant factor in cardiac lesion progression.

Purpose of the Study:

  • To review the key events and effectors of inflammation following myocardial ischemic insult.
  • To examine the role of inflammation in cardiac recovery after MI.
  • To understand the contribution of inflammation to atherosclerosis progression.

Main Methods:

  • Literature review of inflammatory processes after myocardial ischemia.
  • Analysis of cellular and molecular mediators of cardiac inflammation.
  • Examination of the link between inflammation and atherosclerotic disease progression.

Main Results:

  • Inflammation is a critical, yet often detrimental, component of the post-MI healing process.
  • The magnitude and timing of the inflammatory response significantly impact myocardial lesion size and clinical outcomes.
  • Inflammatory pathways activated by MI also contribute to the underlying atherosclerotic process.

Conclusions:

  • Targeting and modulating inflammatory responses represent a promising therapeutic strategy for improving cardiac recovery after MI.
  • A balanced inflammatory response is essential for optimal myocardial healing.
  • Understanding inflammation's dual role in MI and atherosclerosis is key for developing effective treatments.