Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.4K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.4K
Genetics of Speciation02:16

Genetics of Speciation

21.9K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.9K
What is Population Genetics?01:25

What is Population Genetics?

65.0K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.0K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.4K
Overview
80.4K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

31.1K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
31.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosis and Management of Patent Foramen Ovale for Stroke Prevention: An Australian and New Zealand Consensus Statement Developed by a Modified Nominal Group Approach.

The Medical journal of Australia·2026
Same author

Emerging Topics in Neurogenomics: Summary From Inaugural Child Neurology Society Genetics Summit.

Pediatric neurology·2026
Same author

Early Vigabatrin Treatment Before Seizure Onset Decreased Interictal Epileptiform Discharges Over the Duration of the PREVeNT Study.

Pediatric neurology·2026
Same author

Aotearoa New Zealand's neurologist workforce: a 2024 analysis of demand, supply and projections.

BMJ neurology open·2026
Same author

The clinical association of left atrial appendage thrombus on CTA with functional outcome.

European stroke journal·2026
Same author

The clinical association of left atrial appendage thrombus on CTA with functional outcome.

European stroke journal·2025

Related Experiment Video

Updated: Feb 14, 2026

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring
11:28

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Published on: June 13, 2025

1.4K

Genetics of epilepsy.

Danielle Nolan1, John Fink2

  • 1Departments of Pediatrics and Pediatric Neurology, University of Michigan, Ann Arbor, MI, United States.

Handbook of Clinical Neurology
|February 27, 2018
PubMed
Summary
This summary is machine-generated.

Genetic discoveries are revolutionizing epilepsy understanding, identifying nearly 200 genes and pathways. While many previously idiopathic epilepsies are now genetic, most causes remain unknown, necessitating clinical and genetic testing algorithms.

Keywords:
GABRA1KCNT2SCN1ASLC2A1channelopathiesepilepsyepileptic encephalopathiesfebrile seizuresmyoclonic seizuresseizures

More Related Videos

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.7K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

13.0K

Related Experiment Videos

Last Updated: Feb 14, 2026

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring
11:28

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Published on: June 13, 2025

1.4K
A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.7K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

13.0K

Area of Science:

  • Neurogenetics
  • Epilepsy Pathophysiology
  • Clinical Genetics

Background:

  • Significant progress in identifying genes linked to epilepsy and understanding molecular/cellular pathways.
  • Recognition of numerous previously "idiopathic" epilepsy disorders as genetic conditions.
  • The etiology of epilepsy remains unknown for a majority of affected individuals.

Purpose of the Study:

  • To present a structured clinical approach for evaluating patients with epilepsy.
  • To introduce an algorithm for guiding clinical and genetic testing in epilepsy diagnosis.
  • To review the spectrum of genes implicated in epilepsy and their associated syndromes.

Main Methods:

  • Development of a clinical algorithm for epilepsy patient assessment.
  • Systematic review of genes associated with various epilepsy syndromes.
  • Integration of genetic testing strategies into the diagnostic workflow.

Main Results:

  • Identification of approximately 200 genes associated with epilepsy.
  • Elucidation of molecular and cellular pathways contributing to seizure disorders.
  • Demonstration of the utility of genetic testing in diagnosing epilepsy.

Conclusions:

  • Genetic insights are transforming epilepsy classification, diagnosis, and treatment.
  • A systematic clinical and genetic testing approach is crucial for undiagnosed epilepsy.
  • Continued research into epilepsy genetics is vital for understanding and managing seizure disorders.