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Updated: Feb 14, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance
M Rhia L Stone1, Mark S Butler1, Wanida Phetsang1
1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Abstract:
Better understanding how multidrug-resistant (MDR) bacteria can evade current and novel antibiotics requires a better understanding of the chemical biology of antibiotic action. This necessitates using new tools and techniques to advance our knowledge of bacterial responses to antibiotics, ideally in live cells in real time, to selectively investigate bacterial growth, division, metabolism, and resistance in response to antibiotic challenge. In this review, we discuss the preparation and biological evaluation of fluorescent antibiotics, focussing on how these reporters and assay methods can help elucidate resistance mechanisms. We also examine the potential utility of such probes for real-time in vivo diagnosis of infections.
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