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Gaps in Knowledge About the Association Between Maternal Periodontitis and Adverse Obstetric Outcomes: An Umbrella
Annie M Vivares-Builes1, Leidy Johana Rangel-Rincón1, Javier Enrique Botero1
1Faculty of Dentistry, Universidad de Antioquia, Medellín, Colombia.
Insights
Maternal periodontitis is linked to adverse pregnancy outcomes like low birth weight, preterm delivery, and preeclampsia. Further research is needed to address gaps in understanding this association.
Area of Science:
- Reproductive Health
- Periodontology
- Maternal-Fetal Medicine
Background:
- Periodontal disease during pregnancy is linked to obstetric and neonatal complications.
- These complications can impact childhood development and adult cardiovascular health.
Purpose of the Study:
- To summarize evidence on the association between maternal periodontitis and obstetric complications.
- To identify research gaps concerning maternal periodontitis and pregnancy outcomes.
Main Methods:
- Umbrella review of systematic reviews and meta-analyses.
- Quality evaluation and descriptive analysis of included studies.
Main Results:
- Nineteen systematic reviews comprising 99 observational studies were analyzed.
- Most reviews found an association between maternal periodontitis and increased risk of low birth weight, preterm delivery, and preeclampsia.
- The strength and significance of this association vary based on study context.
Conclusions:
- Established association between maternal periodontitis and adverse pregnancy outcomes.
- Identified conceptual and methodological gaps require consideration in future research.
Objectives:
Scientific literature has established that the periodontal condition during pregnancy could be associated with obstetric/neonatal morbidity, and these effects have an important relationship with problems during childhood and cardiovascular disease in adulthood. This umbrella review aimed to summarize the results about the association between maternal periodontitis and obstetric complications (low birth weight, preterm delivery, and preeclampsia) and identify the gaps in the scientific literature.
Methods:
An umbrella review of systematic reviews with or without meta-analysis was performed. Quality evaluation and descriptive analysis of the characteristics of the included studies were conducted.
Results:
Nineteen systematic reviews/meta-analyses were considered. In total, the systematic reviews included 99 observational studies. Most of the reviews established an association between maternal periodontitis and a higher risk of low birth weight, preterm delivery, and preeclampsia. The magnitude and statistical significance of this relationship are influenced by the context in which the studies have been conducted. Gaps were identified in the definition/evaluation of periodontal disease, criteria of gestational age for study purposes, and potential confounders, among others.
Conclusions:
Although scientific literature has established an association among the analyzed pathologies, conceptual and methodological gaps were identified, and they should be considered as integral components when this association is investigated.
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