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Variability of daily creatinine excretion in healthy adults
Insights
Creatinine excretion shows low within-subject variability (3.6%) but significant differences between populations. Burmese individuals exhibit lower daily creatinine output but higher excretion per kilogram, suggesting greater muscularity compared to Europeans and North Americans.
Area of Science:
- Biochemistry
- Human Physiology
- Anthropometry
Background:
- Creatinine excretion is a marker influenced by muscle mass and daily physiological variations.
- Understanding variability in creatinine excretion is crucial for accurate physiological assessments and population comparisons.
Purpose of the Study:
- To quantify the within-subject variability of 24-hour creatinine excretion.
- To compare creatinine excretion levels between different ethnic groups, specifically Burmese versus European and North American populations.
- To infer potential differences in muscularity based on creatinine excretion patterns.
Main Methods:
- Measurement of 24-hour urinary creatinine output over 5 consecutive days in 12 healthy subjects.
- Calculation of the within-subject coefficient of variation for creatinine excretion.
- Comparison of daily creatinine excretion (g/d) and creatinine excretion per kilogram of body weight between ethnic groups.
Main Results:
- The mean within-subject coefficient of variation for creatinine excretion was 3.6%, indicating high consistency within individuals.
- Significant inter-subject variability was observed.
- Creatinine excretion was 30-40% lower in Burmese subjects compared to Europeans and North Americans on a per-day basis.
- However, creatinine excretion per kilogram was slightly higher in Burmese subjects.
Conclusions:
- Daily creatinine excretion is highly consistent within individuals.
- Ethnic variations in creatinine excretion exist, with lower daily output in Burmese individuals.
- Higher creatinine excretion per kilogram in Burmese subjects suggests greater relative muscle mass compared to other studied populations.
Abstract:
In order to determine the within-subject variability of creatinine excretion, the 24-h output was measured over 5 consecutive d in 12 subjects. The mean within-subject coefficient of variation was 3.6 per cent. There was much greater variation between subjects. The creatinine excretion in g/d was 30-40 per cent lower in Burmese subjects than in Europeans and North Americans, but the excretion per kg was slightly higher, suggesting that the Burmese are more muscular.