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[Hyperthyroidism and breast cancer: Is there a link?]
E Cordel1, N Reix2, S Molière3
1Unité de sénologie, hôpital de Hautepierre, hôpitaux universitaires de Strasbourg, CHRU, 1, avenue Molière, 67098 Strasbourg cedex 09, France.
Gynecologie, Obstetrique, Fertilite & Senologie
|February 27, 2018
Summary
Women with hyperthyroidism face a moderately increased risk of breast cancer. Early screening and regular breast examinations are recommended for these patients.
Area of Science:
- Endocrinology
- Oncology
Background:
- Hyperthyroidism is a condition involving an overactive thyroid gland.
- Breast cancer is a significant health concern, particularly in women.
Purpose of the Study:
- To review existing literature and determine the association between hyperthyroidism and breast cancer risk.
- To synthesize findings from various study designs, including cohort studies, case-control studies, and meta-analyses.
Main Methods:
- Literature search conducted on the PUBMED database (2002-2017).
- Keywords used: "hyperthyroidism AND breast cancer" and "thyroid AND breast cancer".
- Selection of 22 relevant studies.
Main Results:
- 15 out of 22 studies found a significant link between hyperthyroidism and breast cancer.
- Graves' disease showed a positive association with breast cancer onset, particularly within three years of diagnosis.
- Increased breast cancer risk was noted in overweight and postmenopausal women with hyperthyroidism.
Conclusions:
- Women with hyperthyroidism have a moderately increased risk of breast cancer (Relative Risk < 2).
- Physiopathological hypotheses support this association.
- Annual clinical breast exams and biennial mammograms (from age 50) are advised for hyperthyroid patients.
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