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Updated: Feb 14, 2026

Bottlenose Dolphin Tursiops truncatus Spermatozoa: Collection, Cryopreservation, and Heterologous In Vitro Fertilization
Published on: August 21, 2017
Sound exposure-induced cytokine gene transcript profile changes in captive bottlenose dolphin (Tursiops truncatus)
I-Hua Chen1, Lien-Siang Chou2, Shih-Jen Chou1
1Department of Veterinary Medicine, National Chiayi University, No. 580, Xinmin Rd., Chiayi, Taiwan (R.O.C.).
Abstract:
Cetacean health may be potentially affected by anthropogenic sound. We have initiated investigations on the effect of low-frequency underwater sound on immunological gene transcript profiles of captive bottlenose dolphins (Tursiops truncatus) using a probe-based quantitative gene expression assay. Six immunologic genes (IL-2Rα, -4, -10, -12, TNFα and IFNγ) were selected for analysis using two validated housekeeping genes (PGK1 and HPRT1) as reference genes. Twenty-four blood samples from six clinically healthy individuals and six blood samples from individuals after sound exposures were available. The gene transcript profile of sound-exposed dolphins was consistent with a stress-induced TH2 shift profile as compared to controls. This study may lead to better understanding of the effects of anthropogenic sound on immune responses of cetaceans.
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