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Spontaneous hypertrophic cardiomyopathy in a cynomolgus macaque (Macaca fascicularis)

Shizuka Konishi1, Takashi Kotera1, Masaaki Koga1

  • 1Pharmacokinetics and Safety Assessment Department, Nippon Shinyaku Co., Ltd., 14 Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.

Journal of Toxicologic Pathology
|February 27, 2018
PubMed

Insights

This study details a rare case of hypertrophic cardiomyopathy in a cynomolgus macaque. Autophagosome accumulation in heart cells suggests a stress-related mechanism for this cardiac condition.

Area of Science:

  • Veterinary Pathology
  • Cardiovascular Research
  • Primate Medicine

Background:

  • Cardiomyopathy, a disease of the heart muscle, is uncommon in cynomolgus macaques (Macaca fascicularis).
  • Hypertrophic cardiomyopathy involves thickening of the heart walls.

Keywords:
autophagycynomolgus macaquedisarrayhypertrophic cardiomyopathyvacuolation

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