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Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens
Published on: September 12, 2016
Childhood exposures to discarded needles and other objects potentially contaminated with blood-borne pathogens in
Faisal Kordy1, Astrid Petrich2, Stanley E Read1
1Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario.
Insights
Children exposed to discarded needles face risks of blood-borne pathogens (BBP). Public health interventions are crucial to prevent these community exposures and ensure proper follow-up care.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Discarded needles and sharps pose a risk of blood-borne pathogen (BBP) transmission to children.
- Pathogens of concern include human immunodeficiency virus (HIV), hepatitis B (HBV), and hepatitis C.
Purpose of the Study:
- To retrospectively analyze the epidemiology, management, and outcomes of pediatric BBP exposures in the Toronto community.
- To identify trends and inform public health strategies for preventing childhood exposures.
Main Methods:
- Retrospective study of children under 19 years with community-based exposure to potentially infectious objects (2001-2014).
- Exclusions: sexual and hospital inpatient exposures. Patient identification via HIV testing records.
- Analysis of exposure types, locations, source subject status, and post-exposure management.
Main Results:
- 66 community exposures identified, primarily needlesticks (71.2%). Median age: 6.3 years.
- Exposures occurred outdoors (45.5%), in schools (30.3%), homes (15.2%), and clinics (9.0%).
- Of 11 source subjects, 7 were HIV-infected. 33.3% received HIV post-exposure prophylaxis; 41.2% of unvaccinated children completed HBV vaccine series. No BBP infections documented, but follow-up testing was inadequate in 39.4%.
Conclusions:
- Community-based exposures to contaminated sharps pose a significant risk to children.
- Enhanced public health interventions in schools and community settings are necessary.
- Improved follow-up testing and vaccination protocols are essential to mitigate BBP transmission risk.
Background:
Exposure to discarded needles or other objects put children at risk for infection with blood-borne pathogens (BBP), including human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C.
Objective:
The purpose of this study was to retrospectively analyze the epidemiology, management and outcome of children following such exposures in the greater Toronto community setting.
Methods:
A retrospective study of children <19 years of age who had community-based exposure to objects that could contain BBP between January 2001 and December 2014. Sexual and hospital inpatient exposures were excluded. Patients were identified by medical record review of all children who had HIV testing performed.
Results:
Sixty-six community-based exposures to objects potentially contaminated with BBP were identified (71.2% needlesticks). The median age was 6.3 years (interquartile range 3.8, 7.8). Exposures occurred outdoors in the community (45.5%), in schools (30.3%), homes (15.2%) and community/outpatient clinics (9.0%). Of 11 (16.7%) identified source subjects, 7 were known to be HIV infected. HIV post-exposure prophylaxis was prescribed to 22 (33.3%) children; 15 (71.4%) completed the course. Only 41.2% of previously unvaccinated children were documented to have completed a full HBV vaccine series post-exposure. No blood-borne infections were documented, but only 60.6% had documentation of adequate follow-up testing.
Conclusions:
Enhanced public health interventions in schools and other community settings are needed to reduce childhood risk of exposure to needlesticks or other objects potentially contaminated with BBP.
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