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Related Experiment Video

Updated: Feb 14, 2026

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Vascular Calcification: Is it rather a Stem/Progenitor Cells Driven Phenomenon?

Aleksandra Leszczynska1, J Mary Murphy2

  • 1Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Frontiers in Bioengineering and Biotechnology
|February 27, 2018
PubMed
Summary
This summary is machine-generated.

Vascular calcification (VC) involves ectopic bone and cartilage formation in atherosclerosis. This review explores the role of progenitor cells in VC pathogenesis, challenging existing theories.

Keywords:
atherosclerosispericytesprogenitor cellsstem cellsvascular calcification

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Area of Science:

  • Cardiovascular Biology
  • Cell Biology
  • Vascular Biology

Background:

  • Vascular calcification (VC) is a significant factor in atherosclerosis, a leading cause of morbidity and mortality.
  • Current theories on VC pathogenesis, including response-to-injury and smooth muscle transdifferentiation, are incomplete.
  • The vasculature possesses a remarkable capacity for repair throughout life.

Purpose of the Study:

  • To review the role of circulating and resident progenitor cells in vascular calcification.
  • To discuss intrinsic cellular mechanisms driving ectopic cartilage and bone formation in atherosclerosis.

Main Methods:

  • Literature review focusing on recent advancements in vascular calcification research.
  • Analysis of studies investigating progenitor cell involvement in atherogenesis and VC.

Main Results:

  • Emerging evidence highlights progenitor cells as key players in VC.
  • Intrinsic cellular mechanisms are crucial for determining cell fate in ectopic ossification.

Conclusions:

  • Progenitor cell involvement offers a new perspective on VC pathogenesis.
  • Further research into cellular mechanisms is needed to fully understand and treat VC in atherosclerosis.