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Updated: Feb 14, 2026

Electrophysiological Recordings from the Giant Fiber Pathway of D. melanogaster
Published on: January 14, 2011
Giant Condylomata Acuminata of Buschke-Lowenstein Associated With Paraneoplastic Hypercalcemia
Fredrick Venter1, Arash Heidari1, Macsen Viehweg1
1Kern Medical Center, Bakersfield, CA, USA.
Abstract:
Low-risk human papillomavirus types 6 and 11 can manifest as giant condylomata acuminata (GCA) of Buschke-Lowenstein. Up to 50% of GCA can slowly progress over years to fungating, invasive tumors. The malignant potential is attributed to unique immune evading abilities of the human papillomavirus. A 42-year-old male presented with pain and foul-smelling discharge from his genital warts. The histopathological examination of the mass showed invasive squamous cell carcinoma, and it was associated with paraneoplastic hypercalcemia. The timely removal of long-standing GCA in order to prevent a carcinomatous transition is a priority.
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