Variation among cleft centres in the use of secondary surgery for children with cleft palate: a retrospective cohort

Thomas J Sitzman1,2, Monir Hossain3, Adam C Carle2

  • 1Division of Plastic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

BMJ Paediatrics Open
|February 27, 2018
PubMed

Insights

Significant variation exists in secondary palate surgery rates among US children with cleft palate. Early primary repair before nine months increases the need for revision surgery, highlighting the importance of surgical timing.

Area of Science:

  • Craniofacial Surgery
  • Pediatric Surgery
  • Health Services Research

Background:

  • Secondary palate surgery, or revision palate surgery, is a common follow-up procedure for children with cleft palate.
  • The utilization of secondary palate surgery varies significantly across healthcare facilities.

Purpose of the Study:

  • To determine if cleft palate centers differ in their use of secondary palate surgery.
  • To identify modifiable hospital and surgeon factors associated with secondary surgery rates.

Main Methods:

  • Retrospective cohort study of 4,939 children undergoing primary cleft palate repair from 1999-2013 in 43 US pediatric hospitals.
  • Analysis of time from primary repair to secondary palate surgery.
  • Assessment of hospital and surgeon-level variations in secondary surgery rates.

Main Results:

  • By 10 years post-primary repair, 44% of children had secondary palate surgery, with rates ranging from 9% to 77% across hospitals.
  • Primary palate repair before nine months of age significantly increased the hazard of secondary surgery (HR 6.74).
  • Hospital and surgeon factors explained 59% and 41% of the variation in secondary surgery, respectively; procedure volume and antibiotics were not associated.

Conclusions:

  • Substantial variation in secondary palate surgery rates exists, influenced by age at primary repair, hospital, and surgeon.
  • Performing primary palate repair before nine months of age is linked to a higher likelihood of requiring secondary surgery.
  • Further research is needed to pinpoint specific factors contributing to outcome disparities among centers and surgeons.
Abstract

Related Concept Videos

What is Variation?01:14

What is Variation?

Apart from the measures of central tendency, distribution, outliers, and the changing characteristics of data with time, an important characteristic of any data set is its variation or spread. In some data sets, the data values are concentrated closely near the mean; in others, the data values are more widely spread out from the mean.
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...
18.7K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
6.9K
Variation01:19

Variation

An important characteristic of any set of data is the variation in the data. In some data sets, the data values are concentrated closely near the mean; in other data sets, the data values are more widely spread out from the mean. The most common measure of variation, or spread, is the standard deviation, which is the square root of variance.
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...
8.1K
Secondary Active Transport01:55

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
138.3K
Secondary Healthcare System01:11

Secondary Healthcare System

Secondary healthcare is offered by a specialist, generally in hospitals or clinics for patients referred by primary healthcare providers. It occurs when a person has an illness or injury that requires specific medical care. Secondary care is often referred to as acute care. Secondary care can range from uncomplicated care to repair a minor laceration or treat a strep throat infection to more complicated emergent care, such as treating a head injury sustained in an automobile accident. Whatever...
2.1K
Variation of Atmospheric Pressure01:18

Variation of Atmospheric Pressure

Change in atmospheric pressure with height is particularly interesting. The decrease in atmospheric pressure with increasing altitude is due to the decreasing gravitational force per unit area as we move away from the surface of the earth.
Assuming the air temperature is constant at a given altitude and that the ideal gas law of thermodynamics describes the atmosphere to a good approximation, one can find the variation of atmospheric pressure with height.
Let p(y) be the atmospheric pressure at...
4.2K