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Inflammation01:38

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In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
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Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
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The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
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During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
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Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
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Related Experiment Video

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A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
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The inflammation - cancer connection.

Alberto Mantovani1,2,3

  • 1Humanitas Clinical and Research Center, Milan, Italy.

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Summary
This summary is machine-generated.

This Special Issue explores the link between inflammation and cancer, covering immune-cancer cell interactions and current cancer immunotherapy targets. These reviews offer insights into the complex relationship between the immune system and malignant growth.

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Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Inflammation is increasingly recognized as a significant factor in cancer development and progression.
  • Understanding the intricate crosstalk between immune cells and cancer cells is crucial for developing effective treatments.

Discussion:

  • This collection reviews the multifaceted roles of inflammation in various stages of tumorigenesis.
  • It examines how immune responses can both promote and suppress tumor growth.

Key Insights:

  • Highlights key molecular mechanisms underlying immune-cancer cell communication.
  • Discusses current therapeutic targets in cancer immunotherapy, focusing on modulating immune responses.

Outlook:

  • Future research directions in cancer immunotherapy and the role of inflammation.
  • Potential for novel therapeutic strategies targeting the tumor microenvironment.