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Retinopathy of prematurity in extremely premature infants: multiple births versus single births

İkbal Seza Petriçli, Caner Kara, Nihal Demirel

    Turkish Journal of Medical Sciences
    |February 27, 2018
    PubMed

    Insights

    Multiple births did not increase the risk of retinopathy of prematurity (ROP) in extremely preterm infants. This finding suggests that twin and triplet births do not significantly impact ROP development compared to single births.

    Area of Science:

    • Neonatology
    • Ophthalmology
    • Perinatal Medicine

    Background:

    • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in preterm infants.
    • Extremely preterm infants (≤27 weeks gestational age) are at high risk for ROP.
    • The impact of multiple births on ROP incidence requires further investigation.

    Purpose of the Study:

    • To compare the incidence of any stage of ROP and severe ROP (Type 1 ROP) between extremely preterm multiple-birth and single-birth infants.
    • To identify risk factors associated with ROP development in this vulnerable population.

    Main Methods:

    • Retrospective study of extremely preterm infants (≤27 weeks gestational age).
    • Infants categorized into single-birth and multiple-birth groups.
    • Comparison of ROP incidence (any stage and Type 1) between the groups using statistical analysis.

    Main Results:

    • The study included 301 infants (225 singletons, 76 multiples).
    • Overall ROP incidence was 70.7%, with Type 1 ROP at 16.6%.
    • Lower birth weight and longer hospital stay were correlated with ROP; however, multiple birth was not a significant risk factor for ROP or Type 1 ROP.

    Conclusions:

    • Multiple birth status does not significantly increase the risk of developing any stage of ROP or Type 1 ROP in extremely preterm infants.
    • Clinical management of ROP in extremely preterm infants should consider factors beyond birth multiplicity.

    Keywords:
    Retinopathy of prematurityextremely preterm infantsmultiple birth

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