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The relationship between BDNF Val66Met polymorphism and functional mobility in chronic stroke survivors
Margaret A French1,2, Susanne M Morton1,2, Ryan T Pohlig3
1a Department of Physical Therapy, College of Health Sciences , University of Delaware , Newark , DE , USA.
Topics in Stroke Rehabilitation
|February 27, 2018
Summary
The Brain Derived Neurotrophic Factor (BDNF) Val66Met polymorphism did not significantly impact long-term functional mobility in chronic stroke survivors. Further research is needed to understand recovery predictors post-stroke.
Area of Science:
- Neuroscience
- Genetics
- Rehabilitation Medicine
Background:
- The Brain Derived Neurotrophic Factor (BDNF) Val66Met polymorphism is implicated in stroke recovery, but its long-term effects on functional mobility remain unclear.
- Previous studies have not investigated the BDNF genotype's impact on functional mobility in chronic stroke survivors.
Purpose of the Study:
- To examine the relationship between BDNF genotype (Val66Met) and functional mobility in chronic stroke survivors.
- To determine if BDNF genotype influences long-term functional mobility after accounting for demographic and clinical factors.
Main Methods:
- Sixty-three chronic stroke survivors (≥6 months post-stroke) underwent functional mobility assessments (10 meter walk test), depression screening (Yesavage Geriatric Depression Scale), and BDNF genotype testing.
- Regression models were employed to assess the predictive value of BDNF genotype and its interactions with age, gender, and depression on functional mobility, controlling for physical impairment (Fugl-Meyer Lower Extremity Assessment).
Main Results:
- Physical impairment and personal information significantly predicted functional mobility (10 meter walk test speed).
- The addition of BDNF genotype and its interactions did not significantly improve the prediction of functional mobility.
- Twenty-two percent of participants carried at least one Met allele of the BDNF polymorphism.
Conclusions:
- The Val66Met polymorphism in the BDNF gene does not appear to predict long-term functional mobility in chronic stroke survivors.
- The lack of significant association may be attributed to other model variables or a diminished role of this polymorphism as stroke recovery progresses.
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