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Human Gut Microbiota in Health and Alzheimer's Disease

Leszek Szablewski1

  • 1Medical University of Warsaw, Department of General Biology and Parasitology, Warsaw, Poland.

Journal of Alzheimer'S Disease : JAD
|February 27, 2018
PubMed

Insights

Alterations in gut microbiota composition are linked to Alzheimer's disease (AD) risk. Modulating gut microbiota may decrease AD risk and slow disease progression.

Area of Science:

  • Microbiology
  • Neuroscience
  • Human Health

Background:

  • Gut microbiota significantly influences human health and disease.
  • Changes in gut microbial composition are associated with various pathologies.
  • Alzheimer's disease (AD) is one such pathology linked to gut dysbiosis.

Purpose of the Study:

  • To explore the relationship between gut microbiota and Alzheimer's disease.
  • To identify factors influencing AD risk through gut microbiota.
  • To investigate the potential of microbiota modulation in AD prevention and treatment.

Main Methods:

  • Review of existing literature on gut microbiota and AD.
  • Analysis of factors impacting gut microbiota composition (diet, antibiotics, probiotics, prebiotics).
  • Examination of studies on microbiota modulation strategies for AD.

Main Results:

  • High-fat diets, antibiotic use, and lack of probiotics/prebiotics increase AD risk.
  • Specific alterations in gut microbiota composition are observed in AD patients.
  • Microbiota modulation strategies show potential in reducing AD risk.

Conclusions:

  • Gut microbiota plays a critical role in Alzheimer's disease pathogenesis.
  • Dietary interventions and microbial supplements may mitigate AD risk.
  • Targeting the gut microbiota offers a promising avenue for AD management.
Keywords:
Alzheimer’s diseasedysbiosisgut microbiotametabolic endotoxemiaphysiology

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