Biophysical Approaches to Protein Folding and Disease, a satellite meeting to the IUPAB-EBSA congress

Overview

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...

The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
The...

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...

Thousands of artificial satellites orbit the Earth every day at various distances from the Earth. Satellites that orbit the Earth below an altitude of 1,600 km are considered to be orbiting in low-Earth orbit (LEO). Research satellites and Earth observation satellites are usually placed in LEO, and mostly orbit the Earth in elliptical orbits. Navigation satellites are placed in medium-Earth orbit (MEO), ranging from 2,000 km to 36,000 km from the surface of the Earth. Meanwhile, communication...