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Published on: September 17, 2012
Significance of cytoplasmic cyclin D1 expression in oral oncogenesis
P Ramos-García1, M Bravo1, L González-Ruiz2
1School of Dentistry, University of Granada, Granada, Spain.
Objectives:
To examine cytoplasmic cyclin D1 expression levels in oral carcinogenesis and evaluate their possible oncogenic significance and their clinicopathological and prognostic implications.
Materials And Methods:
Immunohistochemical analysis of 69 oral squamous cell carcinomas (OSCCs) was performed, revealing 23 with cytoplasmic cyclin D1 expression. We analyzed the association of the percentage of cyclin D1-positive cells and the intensity of expression with TNM classification, tumor stage, differentiation degree, cell morphology, and Ki-67 expression.
Results:
Cytoplasmic cyclin D1 expression was associated with advanced tumor stage, poor differentiation, elevated Ki-67 expression, and the presence of invasive cell morphology, indicators of a poor prognosis. An association was observed between nuclear and cytoplasmic expressions of cyclin D1.
Conclusions:
Cytoplasmic expression of cyclin D1 appears to possess functions related to increased cell migration and invasion in OSCC.
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