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Updated: Feb 14, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
Autophagy in the dentin-pulp complex against inflammation
1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOS and Key Laboratory for Oral Biomedicine of Ministry of Education [KLOBM]), School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Abstract:
The dentin-pulp complex is a highly specialized tissue for protecting the dental pulp. Odontoblasts are long-lived, hard-tissue-forming cells in the dentin-pulp complex and critically involved in inflammatory responses against invading pathogens. Autophagy is a highly conserved homeostasis mechanism of living cells under various stress conditions. Growing evidence in the literature addresses the role of autophagy in odontoblast differentiation and aging. This review summarizes the current knowledge about autophagy for the dentin-pulp complex in resisting inflammation.
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