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Exenatide once weekly for smoking cessation: study protocol for a randomized clinical trial
Luba Yammine1, Thomas R Kosten, Paul M Cinciripini
1University of Texas Health Science Center at Houston Baylor College of Medicine University of Texas MD Anderson Cancer Center, Houston, Texas Mind Springs Health, Grand Junction, Colorado.
Medicine
|February 27, 2018
Summary
This study investigates if exenatide, a GLP-1 agonist, can help smokers quit. Researchers aim to see if it reduces cravings and withdrawal symptoms, potentially improving smoking cessation success.
Area of Science:
- Pharmacology
- Addiction Medicine
- Metabolic Diseases
Background:
- Cigarette smoking is a leading preventable cause of death.
- Current smoking cessation therapies have limited efficacy.
- Glucagon-like peptide-1 (GLP-1) agonists show promise in reducing substance use.
Purpose of the Study:
- To evaluate the efficacy of extended-release exenatide in smoking cessation.
- To assess exenatide's impact on smoking urges and withdrawal symptoms.
- To determine if exenatide reduces cue-induced cigarette craving.
Main Methods:
- A 90-participant, double-blind, placebo-controlled randomized trial.
- Participants received exenatide or placebo plus nicotine replacement therapy and counseling.
- Smoking abstinence, craving, and withdrawal were assessed weekly and post-treatment. Cue-induced craving was measured after virtual reality exposure.
Main Results:
- Results are pending as this is a study protocol.
- The study hypothesizes increased smoking abstinence rates with exenatide.
- Exenatide is expected to decrease craving and withdrawal symptoms.
Conclusions:
- Exenatide represents a novel pharmacological approach for smoking cessation.
- Further research is needed to confirm the efficacy of GLP-1 agonists in smoking cessation.
- This trial will provide crucial data on exenatide's role in quitting smoking.
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