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Serum apolipoprotein A2 isoforms in autoimmune pancreatitis
Takashi Kobayashi1, Yu Sato1, Shin Nishiumi1
1Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan.
Biochemical and Biophysical Research Communications
|February 27, 2018
Summary
Serum apolipoprotein A2 (apoA2) isoform distribution differs in autoimmune pancreatitis (AIP). AIP patients show lower apoA2-ATQ/AT levels, suggesting altered apoA2 processing and potential for differential diagnosis.
Area of Science:
- Biochemistry
- Immunology
- Oncology
Background:
- Apolipoprotein A2 (apoA2) isoforms are emerging biomarkers for pancreatic cancer.
- The distribution of apoA2 isoforms in autoimmune pancreatitis (AIP) remains uncharacterized.
Purpose of the Study:
- To investigate the serum apoA2 isoform distribution in AIP patients.
- To compare apoA2 isoform levels between AIP patients and healthy volunteers (HV).
- To assess the potential of apoA2 isoforms in differentiating AIP from pancreatic cancer.
Main Methods:
- Enzyme-linked immunosorbent assays (ELISAs) were used to quantify apoA2 isoforms.
- Serum samples from 32 AIP patients and 38 HV were analyzed.
- Clinical characteristics and serum levels of apoA2-ATQ/ATQ, apoA2-ATQ/AT, and apoA2-AT/AT were evaluated.
Main Results:
- AIP patients exhibited significantly lower serum levels of the apoA2-ATQ/AT isoform compared to HV.
- AIP patients predominantly showed high apoA2-ATQ and low apoA2-AT levels.
- This pattern suggests inhibited processing of the C-terminal regions of the apoA2 dimer in AIP.
Conclusions:
- The specific distribution of serum apoA2 isoforms in AIP patients differs from healthy individuals.
- Altered apoA2 isoform profiles in AIP may reflect disease-specific processing.
- Serum apoA2 isoform analysis could aid in the differential diagnosis of AIP and pancreatic cancer.
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