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Updated: Feb 14, 2026
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Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model
Published on: October 9, 2018
10.2K
Amniotic membrane transplantation for ligneous conjunctivitis in a doberman
Louise O'Leary1, Andrew Specht1, Natalie Isaza1
1Department of Small Animal Clinical Sciences, University of Florida, Gainesville, FL, USA.
Veterinary Ophthalmology
|February 27, 2018
Summary
This study reports the first successful treatment of canine ligneous conjunctivitis using amniotic membrane transplantation. Surgical excision and amniotic membrane grafts resolved chronic pseudomembranes in a Doberman Pinscher.
Area of Science:
- Veterinary Ophthalmology
- Ocular Pathology
Background:
- Canine conjunctivitis can manifest as chronic proliferative inflammation.
- Ligneous conjunctivitis, characterized by thick pseudomembranes, presents a diagnostic and therapeutic challenge in dogs.
Observation:
- A 2-year-old Doberman Pinscher presented with bilateral, chronic proliferative conjunctivitis and dense pseudomembranes obscuring ocular structures.
- Histopathology confirmed ligneous conjunctivitis, despite normal serum plasminogen levels.
Findings:
- Conventional anti-inflammatory and immunosuppressive treatments were ineffective.
- Surgical excision of pseudomembranes followed by amniotic membrane transplantation resulted in complete resolution.
Implications:
- Amniotic membrane transplantation offers a novel and effective therapeutic option for canine ligneous conjunctivitis.
- This case highlights the potential of regenerative medicine in managing severe ocular surface disease in veterinary patients.
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