Related Experiment Video
Updated: Feb 14, 2026

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain
Published on: July 11, 2016
Effect of Bacillus subtilis C-3102 on loose stools in healthy volunteers
M Hatanaka1, K Yamamoto2, N Suzuki2
11 Department of Microbiological Flora Techinology, Core Technology Laboratories, Asahi group holdings Ltd., 5-11-10 Fuchinobe, Chuo-ku, Sagamihara-shi 252-0206, Kanagawa, Japan.
Abstract:
Ingestion of Bacillus subtilis C-3102 spores (C-3102) has relieved the symptoms of diarrhoea in piglets and changed the composition of gut microbiota in humans. Recently, it was suggested that the composition of the human gut microbiota affects stool consistency. In this study, a double-blind, randomised, placebo-controlled trial was conducted to assess the preventive effects of chronic diarrhoea in healthy volunteers with loose stools by ingestion of C-3102. The results showed that oral doses of C-3102 tablets significantly decreased the Bristol Stool Scale score and stool frequency, and also significantly improved abdominal sounds. With regard to gut microbiota, the relative abundance of Lachnospira, Actinomyces and SMB53 were significantly changed. This study shows that C-3102 could be effective for treating loose stools (Trial registration: UMIN000022583, http://tinyurl.com/ya4refqn ).
Related Concept Videos
Loose Connective Tissue
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
Serum Laboratory Studies, Stool Test, Breath Test
Bioavailability Study Design: Healthy Subjects Versus Patients
Bystander Effect
Framing Effects
The Stanford Prison Experiment

