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Avelumab: a new standard for treating metastatic Merkel cell carcinoma

Mairead Baker1,2, Lisa Cordes2,3, Isaac Brownell1,2

  • 1a Dermatology Branch , National Institute of Arthritis and Musculoskeletal and Skin Disorders , Bethesda , MD , USA.

Expert Review of Anticancer Therapy
|February 28, 2018
PubMed
Abstract

Insights

Avelumab, an anti-PD-L1 therapy, offers durable responses for metastatic Merkel cell carcinoma (MCC), a rare skin cancer. This immunotherapy represents a significant advancement over traditional chemotherapy for improving patient survival.

Area of Science:

  • Oncology
  • Immunotherapy
  • Dermatology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer.
  • Traditional chemotherapy offers limited durable responses in metastatic MCC.
  • Avelumab is a novel anti-PD-L1 immune checkpoint inhibitor.

Purpose of the Study:

  • To provide an overview of Merkel cell carcinoma.
  • To summarize the development and efficacy of avelumab for metastatic MCC.
  • To review preclinical and clinical trial data, including safety and future perspectives.

Main Methods:

  • Review of preclinical studies.
  • Analysis of Phase 1 and Phase 2 clinical trials.
  • Evaluation of avelumab's safety profile in MCC patients.

Main Results:

  • Avelumab demonstrated rapid and durable responses in metastatic MCC.
  • The safety profile of avelumab was manageable.
  • Patient outcomes showed favorable comparison to historical chemotherapy responses.

Conclusions:

  • Avelumab is the first FDA-approved agent for metastatic MCC, offering a new treatment option.
  • The immunotherapy shows promise for improving patient survival in advanced MCC.
  • Ongoing trials aim to further define avelumab's role and optimal use in MCC therapy.
Keywords:
AvelumabMerkel cell carcinomaPD-L1antibody-dependent cellular cytotoxicitycheckpoint inhibitorimmunotherapy

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