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Controlling pertussis: how can we do it? A focus on immunization

Federico Martinón-Torres1,2, Ulrich Heininger3, Angus Thomson4

  • 1a Translational Pediatrics and Infectious Diseases , Hospital Clínico Universitario de Santiago , Santiago de Compostela , Spain.

Expert Review of Vaccines
|February 28, 2018
PubMed

Insights

Pertussis outbreaks are increasing due to lower vaccine uptake and waning immunity. Strategies include broader immunization schedules and public confidence in vaccines to control this contagious respiratory disease.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Immunology

Background:

  • Pertussis, caused by Bordetella pertussis, is a highly contagious respiratory illness most severe in infants.
  • Vaccination significantly reduced pertussis incidence, but recent outbreaks signal challenges like insufficient uptake, suboptimal vaccine protection, and waning immunity.
  • Control strategies are crucial, especially in Europe, with global relevance.

Purpose of the Study:

  • To review the major challenges in controlling pertussis.
  • To propose optimal strategies for pertussis control, focusing on immunization.

Main Methods:

  • This review discusses challenges and strategies for pertussis control.
  • Recommendations are based on expert commentary regarding immunization schedules and public confidence.

Main Results:

  • A comprehensive immunization schedule is proposed, including infants, preschoolers, adolescents, adults, and pregnant women.
  • Sustaining public and healthcare provider confidence in vaccination is vital to address vaccine hesitancy and improve uptake.
  • Enhanced regional surveillance is necessary to monitor incidence and outbreaks effectively.

Conclusions:

  • Implementing a multi-stage immunization schedule is key to maximizing vaccine coverage.
  • Addressing vaccine hesitancy and regional surveillance variations are critical for pertussis control.
  • Future development of pertussis vaccines with longer-lasting protection is recommended.
Abstract

Keywords:
Acellular pertussis vaccineBordetella pertussisvaccine hesitancyvaccine schedulewhole-cell pertussis vaccine

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