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Updated: Feb 14, 2026

Transcranial Direct Current Stimulation tDCS in Mice
Published on: September 23, 2018
Duration but not intensity influences transcranial direct current stimulation (tDCS) after-effects on cortical
Philippe Vignaud1, Marine Mondino2, Emmanuel Poulet3
1Inserm U1028, CNRS UMR5292, université Claude-Bernard-Lyon-1, PSYR2 Team, Lyon Neuroscience Research Center, 69000 Lyon, France; Centre Hospitalier Le-Vinatier, Bron, 69677, France; Ludwig-Maximilian University, Department of Psychiatry and Psychotherapy, Munich Center for Brain Stimulation, Nußbaumstraße 7, 80336 Munich, Germany.
Abstract:
Recent studies have shown heterogeneous results regarding the influence of intensity and duration of motor transcranial direct current stimulation (tDCS) on cortical excitability. In this pilot crossover study including 14 healthy participants, we compared the effects of a single session of anodal-tDCS set with two commonly used durations (20 and 30minutes) and intensities (1 and 2mA) on short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF). Regardless of the current intensity, 20minutes of tDCS increased SICI (3ms inter-stimulus interval ISI) and decreased ICF (7ms ISI); 30minutes of tDCS did not affect cortical excitability.
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