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Updated: Feb 14, 2026

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
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Ventricular Ectopy in the Context of Left Ventricular Systolic Dysfunction: Risk Factors and Outcomes Following

Adam Lee1, Russell Denman2, Haris M Haqqani1

  • 1Department of Cardiology, The Prince Charles Hospital, Brisbane, Qld, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Qld, Australia.

Heart, Lung & Circulation
|February 28, 2018
PubMed

Insights

Focal ventricular arrhythmia (VA) ablation improves heart function in most patients with cardiomyopathy (CMP). This study assessed outcomes and risk factors, finding significant recovery of left ventricular function and high freedom from arrhythmia recurrence.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure

Background:

  • Ectopy-mediated cardiomyopathy (EMC) is a reversible cause of left ventricular systolic dysfunction.
  • Identifying risk factors for EMC is crucial for timely intervention.
  • Focal ventricular arrhythmias (VA) can lead to cardiomyopathy.

Purpose of the Study:

  • To evaluate medium-term outcomes of focal VA ablation in patients with cardiomyopathy (CMP).
  • To assess the recovery of left ventricular (LV) function post-ablation.
  • To validate previously reported risk factors for EMC.

Main Methods:

  • Compared outcomes of focal VA ablation in CMP patients versus a control group with normal LV function.
  • Assessed medium-term recovery of LV function and freedom from VA recurrence.
  • Performed univariate and multivariate analyses to identify CMP risk factors.

Main Results:

  • 85% of CMP patients were free from VA recurrence at medium-term follow-up.
  • Median left ventricular ejection fraction (LVEF) improved from 40% to 52% in CMP patients.
  • Male gender was the only persistent predictor of CMP on multivariate analysis.

Conclusions:

  • Focal VA ablation yields satisfactory medium-term outcomes in CMP patients.
  • Significant improvement in LV function is achievable for most patients.
  • Published risk factors for EMC are inconsistent, possibly due to population heterogeneity.
Abstract

Keywords:
Catheter ablationEctopy mediated cardiomyopathyPremature ventricular complexesVentricular arrhythmias

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