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Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
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People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
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Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
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Processes of Self-Presentation01:29

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Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...
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Antigen Presenting Cells01:22

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
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Related Experiment Video

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Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
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A Self-Assembling Whole-Cell Vaccine Antigen Presentation Platform.

Julie Liao1, Daniel R Smith1, Jóhanna Brynjarsdóttir1

  • 1Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Journal of Bacteriology
|February 28, 2018
PubMed
Summary

A new vaccine platform uses Vibrio cholerae biofilms to create a customizable, self-assembling vaccine for infectious diarrhea. This novel approach simplifies production and delivery, offering a cost-effective solution for global health challenges.

Keywords:
Vibrio choleraeantigen presentation platformdiarrheasublingualvaccine

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Area of Science:

  • Microbiology and Immunology
  • Vaccine Development
  • Biofilm Technology

Background:

  • Diarrheal diseases are a leading cause of mortality in children under 5 globally, particularly in resource-poor settings.
  • Existing vaccines for infectious diarrhea are limited, costly, and face challenges in production, distribution, and administration.
  • Bacterial biofilms, often targeted for elimination, present an untapped resource for novel therapeutic applications.

Purpose of the Study:

  • To develop a novel, customizable, and self-assembling vaccine platform utilizing the Vibrio cholerae bacterial biofilm matrix.
  • To create a proof-of-concept live-attenuated whole-cell vaccine for infectious diarrhea.
  • To address obstacles in vaccine production, distribution, and delivery for diarrheal diseases and other mucosal infections.

Main Methods:

  • Exploited the Vibrio cholerae bacterial biofilm matrix for antigen presentation.
  • Developed a live-attenuated whole-cell vaccine with spontaneous self-assembly of secreted protein antigens.
  • Administered the vaccine sublingually to a mouse model.

Main Results:

  • The sublingually administered live-attenuated vaccine conferred protection against Vibrio cholerae challenge in mice.
  • The vaccine elicited antigen-specific IgA production in the stool of vaccinated mice.
  • Demonstrated a self-assembling platform for antigen-boosted vaccines, simplifying production and delivery.

Conclusions:

  • The novel biofilm-based vaccine platform is simple to produce and deliver, addressing key barriers to vaccination against diarrheal diseases.
  • This platform serves as a proof of concept for multivalent vaccines against enteric pathogens.
  • The technology offers a paradigm for developing broadly protective, biofilm-based vaccines for other mucosal infections.