Related Experiment Video
Updated: Aug 14, 2026
07:09
Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
Impaired Coagulation Status in the Crohn's Disease Patients Complicated with Intestinal Fistula
Yuan Li1, Jian-An Ren1, Ge-Fei Wang1
1Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, China.
Chinese Medical Journal
|February 28, 2018
Summary
Crohn's disease (CD) with intestinal fistula significantly impairs coagulation, showing longer prothrombin time and lower platelet counts. Surgical resection of fistulas can improve coagulation status in CD patients.
Area of Science:
- Gastroenterology
- Hematology
- Surgical Complications
Background:
- Intestinal fistula is a frequent complication of Crohn's disease (CD), often necessitating surgical intervention.
- CD patients with intestinal fistulas exhibit distinct clinical characteristics and outcomes compared to those without.
- The impact of intestinal fistulas on the coagulation status of CD patients remains an area requiring investigation.
Purpose of the Study:
- To investigate alterations in coagulation status in Crohn's disease patients with intestinal fistulas.
- To compare coagulation parameters between CD patients with and without intestinal fistulas.
- To assess the effect of intestinal fistula resection on coagulation parameters in CD patients.
Main Methods:
- Retrospective analysis of 190 Crohn's disease patients diagnosed between January 2014 and September 2015.
- Collection of baseline clinical characteristics and laboratory indices, including coagulation parameters, at initial admission and 7 days post-resection.
- Statistical comparison using Student's t-test and Wilcoxon rank-sum test to identify significant differences between groups.
Main Results:
- Patients with intestinal fistulas had significantly prolonged prothrombin time (PT) and lower platelet (PLT) counts compared to those without.
- Multivariate analysis confirmed that intestinal fistula is independently associated with prolonged PT and reduced PLT count.
- Following intestinal fistula resection in 65 patients, a significant improvement in PT was observed.
Conclusions:
- Intestinal fistula is significantly associated with impaired coagulation status in Crohn's disease patients.
- Coagulation parameters, particularly prothrombin time, show improvement after surgical resection of intestinal fistulas.
- These findings highlight the importance of monitoring and managing coagulation status in CD patients with intestinal fistulas.
Related Concept Videos
01:17Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:21Inflammatory Bowel Disease V: Surgical Management
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...