Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

62.4K
Overview
62.4K
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

1.3K
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
1.3K
CNS Depressants: Barbiturates and Benzodiazepines01:14

CNS Depressants: Barbiturates and Benzodiazepines

1.4K
CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
1.4K
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

849
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
849
Reducing Line Loss01:18

Reducing Line Loss

395
In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
395
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

920
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
920

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Grey matter degeneration during multiple sclerosis is linked to activation of neuronal necroptosis by oxidized phosphatidylcholines.

Research square·2026
Same author

Challenges and future directions for multiple sclerosis after the 2024 McDonald diagnostic criteria.

Nature medicine·2026
Same author

Autoantigen mRNA-LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Gaining biological insights through supervised data visualization.

Nature computational science·2026
Same author

Cerebellar magnetization transfer ratio and its relationship to clinical outcomes in radiologically isolated syndrome and multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Comparative effectiveness of ocrelizumab in subgroups of patients with multiple sclerosis: a multi-registry observational cohort study.

Journal of neurology, neurosurgery, and psychiatry·2026

Related Experiment Video

Updated: Feb 14, 2026

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

14.9K

EGFL7 reduces CNS inflammation in mouse.

Catherine Larochelle1,2,3, Timo Uphaus1, Bieke Broux2,3

  • 1Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

Nature Communications
|February 28, 2018
PubMed
Summary

Epidermal growth factor-like protein 7 (EGFL7) limits immune cell entry into the central nervous system (CNS). This protein may offer a new therapeutic strategy for multiple sclerosis (MS) by reducing CNS immune infiltration.

More Related Videos

Author Spotlight: Understanding the Mechanism of Tuina Manipulation in Rats
05:50

Author Spotlight: Understanding the Mechanism of Tuina Manipulation in Rats

Published on: June 30, 2023

3.4K
Author Spotlight: Insight Into Advances in Prion Diseases Research
10:40

Author Spotlight: Insight Into Advances in Prion Diseases Research

Published on: August 11, 2023

858

Related Experiment Videos

Last Updated: Feb 14, 2026

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

14.9K
Author Spotlight: Understanding the Mechanism of Tuina Manipulation in Rats
05:50

Author Spotlight: Understanding the Mechanism of Tuina Manipulation in Rats

Published on: June 30, 2023

3.4K
Author Spotlight: Insight Into Advances in Prion Diseases Research
10:40

Author Spotlight: Insight Into Advances in Prion Diseases Research

Published on: August 11, 2023

858

Area of Science:

  • Neuroimmunology
  • Cell Biology
  • Vascular Biology

Background:

  • Extracellular matrix (ECM) proteins secreted by blood-brain barrier (BBB) endothelial cells (ECs) influence cell trafficking.
  • The role of ECM protein epidermal growth factor-like 7 (EGFL7) in central nervous system (CNS) diseases is not fully understood.

Purpose of the Study:

  • To investigate the role of EGFL7 in multiple sclerosis (MS) pathogenesis and its potential as a therapeutic target.
  • To determine how EGFL7 expression and function affect immune cell infiltration in the CNS.

Main Methods:

  • Analysis of EGFL7 expression in CNS vasculature of MS patients and EAE mouse models.
  • Investigating T cell interaction with EGFL7 using integrin αvβ3.
  • Utilizing EGFL7-knockout (KO) mice and EC-restricted EGFL7-KO mice to study EAE.
  • Administering recombinant EGFL7 to EAE mice to assess therapeutic effects.

Main Results:

  • EGFL7 expression is upregulated in the CNS vasculature in MS and experimental autoimmune encephalomyelitis (EAE).
  • Activated T cells bind to EGFL7 via integrin αvβ3, and EGFL7 deficiency exacerbates EAE with increased immune cell infiltration.
  • Treatment with recombinant EGFL7 ameliorates EAE, reduces MCAM expression, and enhances BBB integrity.

Conclusions:

  • EGFL7 plays a protective role by limiting CNS immune cell infiltration in MS.
  • EGFL7 represents a potential novel therapeutic target for managing MS and related neuroinflammatory conditions.