Objective Test of Cochlear Dead Region: Electrophysiologic Approach using Acoustic Change Complex
Soojin Kang1,2, Jihwan Woo2, Heesung Park1
1Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Scientific Reports
|February 28, 2018
Summary
This study introduces a new electrophysiologic method using acoustic change complex (ACC) and threshold-equalizing noise (TEN) to objectively identify cochlear dead regions (CDRs). The TEN-ACC test successfully detected CDRs in hearing-impaired individuals.
Area of Science:
- Audiology
- Neurophysiology
- Hearing Science
Background:
- Cochlear dead regions (CDRs) impair hearing by indicating areas of significant cochlear damage.
- Objective diagnostic methods for CDRs are needed to improve audiological assessments.
Purpose of the Study:
- To develop and validate an objective, neurophysiologic method for detecting cochlear dead regions (CDRs).
- To combine acoustic change complex (ACC) responses with the threshold-equalizing noise (TEN) test for CDR identification.
Main Methods:
- The study involved two phases: confirming ACC evoked by TEN stimuli and optimizing test conditions, then assessing the TEN-ACC test's ability to detect CDRs.
- ACC responses were recorded, and masked thresholds (TEN threshold and TEN-ACC threshold) were measured in normal-hearing (NH) and hearing-impaired (HI) listeners.
- HI listeners were categorized into non-CDR and CDR groups based on behavioral TEN testing.
Main Results:
- ACC responses were successfully recorded in all participants.
- TEN-ACC thresholds were comparable to behavioral TEN thresholds in NH and HI (non-CDR) listeners (below 12 dB SNR).
- Significantly elevated TEN-ACC thresholds (≥12 dB SNR) were observed in HI listeners with CDRs, distinguishing them from NH and HI (non-CDR) groups.
Conclusions:
- The developed TEN-ACC test provides an objective, electrophysiologic method for detecting cochlear dead regions.
- This neurophysiologic approach offers a valuable tool for audiological diagnosis of CDRs.
More Related Videos
03:49Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation
Published on: October 11, 2024
1.2K
07:00Electrically Evoked Stapedius Reflex Measurements in Cochlear Implantation and Its Application in the Postoperative Fitting Process
Published on: June 21, 2024
1.5K
Related Concept Videos
02:40The Eukaryotic Promoter Region
19.0K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences. The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
19.0K
01:18Velocity of an Object
208
Understanding how an object moves along a path requires distinguishing between motion over a time span and motion at a precise moment. A useful example is a vehicle traveling along a straight and level path, where its position at any given time is known. The initial step in analyzing this motion is to measure how far the vehicle travels over a fixed time period. This measurement, called average velocity, is computed by dividing the total change in position by the duration over which the change...
208
01:03IR Frequency Region: Fingerprint Region
2.0K
IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
2.0K
01:50Global Climate Change
29.1K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
29.1K
01:20Rates of Change
136
The rate of change is a central concept in mathematics that quantifies how one variable varies in response to another. It serves as a foundational tool in modeling dynamic systems across disciplines such as physics, biology, economics, and engineering. Understanding both average and instantaneous rates of change enables the analysis of behavior in functions that describe real-world phenomena.Average Rate of ChangeFor a function f(x) defined over an interval [x1,x2], the average rate of change...
136
01:17Work Done During Volume Change
5.2K
In mechanics, work is done on an object when the force acting on it displaces the object. In thermodynamics, work done on a system can be estimated when the system's volume changes during any thermodynamic process.
Consider a gas confined to a cylinder fitted with a movable piston at one end. If the gas expands from volume V1 to volume V2, it exerts a force on the piston, such that the piston moves by a distance dr.
The work done by the gas on the piston can be expressed as
Consider a gas confined to a cylinder fitted with a movable piston at one end. If the gas expands from volume V1 to volume V2, it exerts a force on the piston, such that the piston moves by a distance dr.
The work done by the gas on the piston can be expressed as
5.2K