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Dermatofibrosarcoma Protuberans: Retrospective Single Center Analysis Over 16 Years.
Uwe Wollina1, Dana Langner2, Jacqueline Schönlebe3
1Städtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen, Germany.
Open Access Macedonian Journal of Medical Sciences
|February 28, 2018
Summary
Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer. Wide surgical excision with margin control effectively treated patients, showing no recurrence or metastasis in this study.
Area of Science:
- Oncology
- Dermatology
- Surgical Pathology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare mesenchymal neoplasm.
- DFSP has a high risk of local recurrence but low metastatic potential.
- Tumor cells characteristically express CD34 and exhibit a t(17;22) translocation.
Purpose of the Study:
- To analyze documented cases of DFSP treated at a specific dermatology department.
- To evaluate the efficacy of wide surgical excision with three-dimensional histologic margin control for DFSP.
- To discuss prognostic factors and novel therapeutic approaches for DFSP.
Main Methods:
- Retrospective analysis of DFSP cases diagnosed between August 2001 and August 2017.
- Histological and immunohistological confirmation of all diagnoses.
- Treatment involved wide surgical excision with meticulous three-dimensional histologic margin assessment.
Main Results:
- Four adult and one pediatric patient with DFSP were identified.
- All patients treated with wide surgical excision and margin control showed no recurrence.
- No metastatic spread was observed in any of the treated patients.
Conclusions:
- Wide surgical excision combined with three-dimensional histologic margin control appears to be a highly effective treatment for DFSP.
- This approach can prevent local recurrence and metastatic spread.
- Further research into prognostic factors and emerging treatments is warranted.
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