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Generation of Human Chimeric Antigen Receptor Regulatory T Cells
Published on: January 3, 2025
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Regulatory T cells in renal disease
Maliha A Alikhan1, Megan Huynh1, A Richard Kitching1,2,3
1Centre for Inflammatory Diseases Department of Medicine Monash University Monash Medical Centre Clayton Victoria Australia.
Clinical & Translational Immunology
|February 28, 2018
Summary
Regulatory T cells (Tregs) protect the kidney from injury by suppressing immune responses. Harnessing Tregs, especially antigen-specific ones, offers therapeutic potential for various kidney diseases.
Area of Science:
- Immunology
- Nephrology
- Cell Biology
Background:
- Kidneys are susceptible to acute and chronic injury involving inflammation.
- Regulatory T cells (Tregs) modulate immune responses in kidney diseases like glomerulonephritis and transplantation.
- Abnormalities in Treg number or phenotype are observed in human renal diseases.
Purpose of the Study:
- To review the role of intrarenal Tregs in kidney injury and disease.
- To explore mechanisms of Treg recruitment and function within the kidney.
- To discuss the therapeutic potential of different Treg subsets in renal diseases.
Main Methods:
- Review of experimental and clinical evidence on Tregs in kidney disease.
- Analysis of Treg recruitment pathways (e.g., CCR6, CXCR3, TLR9).
- Examination of Treg subtypes (e.g., tTregs, iTregs, Tr1 cells, antigen-specific Tregs).
Main Results:
- Intrarenal Tregs exert suppressive effects on immune and kidney cells.
- Antigen-specific Tregs play a role in HLA-mediated protection in autoimmune glomerulonephritis.
- Tregs demonstrate protective effects against kidney injury in various experimental models.
- Treg function can be context-dependent, involving factors like Tbet and STAT-3 expression.
Conclusions:
- Tregs are crucial for modulating immune responses and protecting the kidney.
- Targeting Tregs, including induced and antigen-specific types, holds significant therapeutic promise for renal transplantation and other kidney diseases.
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