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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

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Human FOXP3+ T regulatory cell heterogeneity

Audrey Mohr1, Rajneesh Malhotra2, Gaell Mayer3

  • 1Sorbonne Université Inserm Centre d'immunologie et des maladies infectieuses-Paris (Cimi-Paris) AP-HP Hôpital Pitié-Salpêtrière Paris France.

Clinical & Translational Immunology
|February 28, 2018
PubMed

FOXP3-expressing CD4+ T regulatory (Treg) cells are instrumental for the maintenance of self-tolerance. They are also involved in the prevention of allergy, allograft rejection, foetal rejection during pregnancy and of exaggerated immune response towards commensal pathogens in mucosal tissues. They can also prevent immune responses against tumors and promote tumor progression. FOXP3-expressing Treg cells are not a homogenous population. The different subsets of Treg cells can have different functions or roles in the maintenance of immune homeostasis and can therefore be differentially targeted in the management of autoimmune diseases or in cancer. We discuss here how Treg cell subsets can be differentiated phenotypically, functionally and developmentally in humans.

Keywords:
epigeneticsimmunotherapyregulatory T cells

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