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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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Progressive multiple sclerosis, cognitive function, and quality of life.

Helene Højsgaard Chow1, Karen Schreiber1, Melinda Magyari1

  • 1Department of Neurology Danish Multiple Sclerosis Center Rigshospitalet University of Copenhagen Copenhagen Denmark.

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|February 28, 2018
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Summary
This summary is machine-generated.

Cognitive function, not physical ability, more strongly impacts quality of life for patients with progressive multiple sclerosis (MS). This highlights the importance of assessing cognitive health in MS care.

Keywords:
cognitive functionmultiple sclerosisphysical functionprogressive multiple sclerosisquality of life

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Area of Science:

  • Neurology
  • Neuroscience
  • Rehabilitation Medicine

Background:

  • Progressive multiple sclerosis (MS) frequently involves both cognitive and physical impairments.
  • These impairments significantly affect patients' quality of life over time.

Purpose of the Study:

  • To determine the correlation between quality of life and physical/cognitive function in progressive MS patients.
  • To investigate which functional measures best predict quality of life.

Main Methods:

  • Retrospective analysis of 52 progressive MS patients (18 primary progressive, 34 secondary progressive).
  • Assessed physical function using Expanded Disability Status Scale, Timed 25 Foot Walk (T25FW), and 9-Hole Peg Test (9HPT).
  • Evaluated cognitive function with Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test, and Trail Making Test B (TRAIL-B). Quality of life measured by SF-36.

Main Results:

  • Cognitive function measures (SDMT, TRAIL-B) showed significant correlations with overall quality of life (SF-36) and its mental component summary.
  • The Timed 25 Foot Walk (T25FW) test correlated with the Physical Component Summary of the SF-36.
  • A potential link was observed between 9HPT (nondominant hand) and cognitive tests (SDMT, TRAIL-B).

Conclusions:

  • Cognitive function measures are more closely associated with quality of life in progressive MS than physical measures.
  • Cognitive assessments should be integrated into routine evaluations for progressive MS patients.
  • Findings emphasize the critical role of cognitive health in managing MS patient well-being.