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Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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Alternative RNA Splicing02:18

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RNA Splicing01:32

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Null and Alternative Hypotheses01:16

Null and Alternative Hypotheses

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The actual hypothesis testing begins by considering two hypotheses. They are termed  the null hypothesis and the alternative hypothesis. These hypotheses contain opposing viewpoints.
The null hypothesis, denoted by H0 is a statement of no difference between the variables—they are not related. This can often be considered the status quo. As  a result if you cannot accept the null, it requires some action.
The alternative hypothesis, denoted by H1 or Ha, is a claim about the...
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Chromatin Structure and RNA Splicing02:41

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Related Experiment Video

Updated: Feb 13, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

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Alternative Splicing in Neurogenesis and Brain Development.

Chun-Hao Su1, Dhananjaya D1,2, Woan-Yuh Tarn1,2

  • 1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Frontiers in Molecular Biosciences
|February 28, 2018
PubMed
Summary

Alternative splicing significantly impacts brain development and neurogenesis by regulating gene expression. Understanding these splicing mechanisms is crucial for diagnosing and treating brain disorders.

Keywords:
alternative splicingneurogenesisneuronal developmentneuronal differentiationneuronal migrationsplicing factors

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Area of Science:

  • Molecular Biology
  • Neuroscience
  • Genetics

Background:

  • Alternative splicing of precursor mRNA enhances transcriptomic and proteomic diversity.
  • It plays a critical role in nervous system development, influencing cell-fate decisions, neuronal migration, axon guidance, and synaptogenesis.
  • Alternative splicing is highly prevalent in brain tissues.

Purpose of the Study:

  • To review recent advancements in understanding the role of alternative splicing in neurogenesis and brain development.
  • To highlight the impact of alternative splicing on neuronal development and function.
  • To explore the connection between splicing defects and brain disorders.

Main Methods:

  • Genetic manipulation and RNA sequencing provide insights into molecular mechanisms.
  • Analysis of neuron-specific splicing regulators and their roles.
  • Examination of alternative splicing's modulation of signaling, centriolar dynamics, and metabolic pathways.

Main Results:

  • Alternative splicing regulates stem cell self-renewal and neuronal fate specification.
  • It reprograms the transcriptome by affecting transcription regulators and epigenetic factors.
  • Alternative splicing influences cortical lamination and overall neuronal development and function.

Conclusions:

  • Alternative splicing is a key regulator of neurogenesis and brain development.
  • Defects in splicing processes can lead to various brain disorders and diseases.
  • Further research into alternative splicing mechanisms is vital for understanding brain health and disease.