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Conundrum of a Large Bowel Neoplasm: Collision Tumor
Antonio R Soto1, Ekie G Vazquez1, Nicole M Grigg-Gutierrez1
1Department of Gastroenterology, VA Caribbean Healthcare System, San Juan, Puerto Rico.
ACG Case Reports Journal
|February 28, 2018
Summary
A rare case of colliding cancers in the colon was discovered: adenocarcinoma and diffuse large B-cell lymphoma. This finding highlights the complexity of gastrointestinal malignancies.
Area of Science:
- Gastroenterology and Oncology
- Colorectal Cancer Research
- Lymphoma Studies
Background:
- Colorectal cancer and lymphoma are distinct malignancies.
- Co-occurrence of these cancers is exceptionally rare.
- Diagnostic challenges in differentiating primary vs. secondary lesions.
Observation:
- A 79-year-old male presented with anemia and diarrhea.
- Imaging revealed colonic thickening and lymphadenopathy.
- Colonoscopy identified aphthous ulcers and a deep rectosigmoid ulcer.
Findings:
- Histology confirmed ulcerative colitis and adenocarcinoma.
- The deep ulcer harbored a well-differentiated adenocarcinoma.
- Colectomy specimen revealed colliding diffuse large B-cell lymphoma and adenocarcinoma.
Implications:
- This case underscores the importance of thorough histopathological examination for accurate diagnosis.
- Understanding colliding malignancies is crucial for effective treatment strategies.
- Further research into the pathogenesis of co-occurring colorectal cancers is warranted.
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