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Related Experiment Video

Updated: Feb 13, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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Physical Activity and Changes in White Matter Hyperintensities over Three Years.

S Y Moon1, P de Souto Barreto, M Cesari

  • 1So Young Moon, MD, PhD, Department of Neurology, School of Medicine, Ajou University, 5 San, Woncheon-dong, Yongtong-gu, Suwon-si, Kyunggi-do, 442-749, Republic of Korea, Tel: +82-31-219-5175, Fax: +82-31-219-5178,

The Journal of Nutrition, Health & Aging
|February 28, 2018
PubMed
Summary

Physical activity (PA) did not significantly slow white matter hyperintensities (WMH) progression in older adults. However, a decrease in PA over time showed a trend towards greater WMH progression, suggesting maintaining activity is important.

Keywords:
Physical activitylongitudinalwhite matter hyperintensities

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Area of Science:

  • Neurology
  • Gerontology
  • Cardiovascular Health

Background:

  • Physical activity (PA) is known to benefit cardiovascular health.
  • White matter hyperintensities (WMH) are common in older adults and linked to cognitive decline.
  • The relationship between PA and WMH progression in non-demented older adults with memory complaints requires further investigation.

Purpose of the Study:

  • To investigate the association between physical activity (PA) and the progression of white matter hyperintensities (WMH).
  • To examine if higher or increasing PA levels slow WMH progression in non-demented older adults experiencing memory complaints.

Main Methods:

  • 152 non-demented older adults with memory complaints were analyzed.
  • Self-reported PA (MET-minute/week) and WMH volume were assessed at baseline and 3-year follow-up using MRI.
  • Mixed-effect linear regression models were used to analyze the association between PA and WMH progression.

Main Results:

  • No significant association was found between baseline PA levels and WMH progression.
  • A trend suggested that decreased PA over three years was associated with greater WMH progression in unadjusted models (p=0.045).
  • This trend lost statistical significance after adjusting for confounding factors (p=0.096).

Conclusions:

  • No significant association was found between physical activity and white matter hyperintensities progression in this cohort.
  • A decrease in physical activity levels over time showed a tendency towards greater WMH progression.
  • Larger longitudinal studies using objective PA measures are recommended to clarify this relationship.