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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Vitamin D supplementation improves endothelial dysfunction in patients with non-dialysis chronic kidney disease

Qingyan Zhang1, Miao Zhang1, Hengjin Wang1

  • 1Department of Nephrology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, 321 Zhong Shan Road, Nanjing, 210008, China.

International Urology and Nephrology
|February 28, 2018
PubMed

Insights

Vitamin D supplementation improved endothelial dysfunction in chronic kidney disease (CKD) patients. This study showed increased flow-mediated dilation and reduced soluble endothelial biomarkers after vitamin D treatment.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Hypovitaminosis D is prevalent in chronic kidney disease (CKD) patients.
  • Low vitamin D levels are linked to endothelial dysfunction and increased cardiovascular risk in CKD.

Purpose of the Study:

  • To evaluate the impact of vitamin D supplementation on endothelial dysfunction in non-dialysis CKD patients.
  • To assess changes in flow-mediated dilation (FMD) and endothelial biomarkers following vitamin D treatment.

Main Methods:

  • Seventy-one non-dialysis CKD patients with low vitamin D levels were enrolled.
  • Participants received oral cholecalciferol (50,000 units weekly) for 12 weeks.
  • Endothelial function was assessed using FMD, sVCAM-1, and sE-selectin measurements.

Main Results:

  • Vitamin D supplementation significantly increased serum 25(OH)D levels.
  • Flow-mediated dilation (FMD) showed a significant improvement.
  • Levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and sE-selectin decreased significantly.

Conclusions:

  • Vitamin D supplementation effectively improves endothelial dysfunction in pre-dialysis CKD patients.
  • This intervention may offer a therapeutic strategy to mitigate cardiovascular risk in this population.
Abstract

Keywords:
CholecalciferolChronic kidney diseaseEndothelial dysfunctionVitamin D

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