Related Experiment Video
Updated: Feb 13, 2026
09:36
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
26.3K
The BRAF activated non-coding RNA: A pivotal long non-coding RNA in human malignancies
Xiu-Fen Liu1, Ji-Long Hao1, Tian Xie2
1Department of Ophthalmology, The First Hospital of Jilin University, Jilin, China.
Cell Proliferation
|February 28, 2018
Summary
Long non-coding RNAs (lncRNAs), like BRAF activated non-coding RNA (BANCR), are crucial in cancer. This review explores BANCR
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) are integral to cancer development and progression.
- BRAF activated non-coding RNA (BANCR) was initially identified as an oncogenic lncRNA in melanoma.
- BANCR's role extends beyond melanoma, implicating it in various human malignancies.
Purpose of the Study:
- To review the current research on the expression patterns of BANCR in different human cancers.
- To elucidate the multifaceted roles of BANCR in tumorigenesis and cancer progression.
- To highlight BANCR's potential as a diagnostic biomarker and therapeutic target.
Main Methods:
- Literature review of studies investigating BANCR expression and function in various cancers.
- Analysis of experimental data on BANCR's involvement in cellular processes like migration.
- Synthesis of findings regarding BANCR's dual role as a tumor suppressor or accelerator.
Main Results:
- BANCR expression profiles differ across various cancer types.
- BANCR influences cancer cell migration and other progression-related mechanisms.
- Evidence suggests BANCR can act as either a tumor suppressor or an oncogene depending on the cancer context.
Conclusions:
- BANCR is a significant player in the complex landscape of human malignancies.
- BANCR holds promise as a biomarker for cancer diagnosis and prognosis.
- Targeting BANCR may offer novel therapeutic strategies for cancer treatment.
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