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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Anti-cancer therapy with TNFα and IFNγ: A comprehensive review
Jing Shen1, Zhangang Xiao1, Qijie Zhao1
1Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Cell Proliferation
|February 28, 2018
Summary
Tumour necrosis factor alpha (TNFα) and interferon gamma (IFNγ) are key immune molecules with potent anti-cancer effects. This review highlights recent advancements in using these cytokines for novel cancer therapies.
Area of Science:
- Immunology
- Molecular Biology
- Oncology
Background:
- Tumour necrosis factor alpha (TNFα) and interferon gamma (IFNγ) are crucial cytokines produced by inflammatory cells.
- These molecules play vital roles in immune surveillance against tumour growth.
Purpose of the Study:
- To review recent advancements in the anti-cancer applications of TNFα and IFNγ.
- To discuss the therapeutic potential of these cytokines in cancer treatment.
Main Methods:
- Review of existing literature on TNFα and IFNγ signaling pathways.
- Analysis of studies investigating the anti-cancer effects of TNFα and IFNγ.
- Discussion of novel therapeutic strategies involving these cytokines.
Main Results:
- TNFα and IFNγ activate distinct signaling pathways including NF-κB, MAPK, and JAK/STAT.
- These cytokines effectively induce cancer cell death.
- Both TNFα and IFNγ exhibit powerful anti-cancer effects.
Conclusions:
- TNFα and IFNγ hold significant promise for innovative cancer therapies.
- Further research into their mechanisms and applications can lead to improved anti-cancer treatments.
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