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Updated: Feb 13, 2026

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
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[ENDOTHELIAL DYSFUNCTION: A POSITION PAPER OF THE ISRAEL HEART SOCIETY]

Michael Shechter1, Ofer Amir1, Amir Lerman1

  • 1Israel Heart Society.

Harefuah
|February 28, 2018
PubMed

Insights

Assessing endothelial function can improve cardiovascular risk prediction beyond traditional scores. This review covers methods and suggests integrating these tests into clinical practice for personalized medicine.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Preventive Cardiology

Background:

  • Traditional coronary artery disease (CAD) risk scores (e.g., SCORE, Framingham) have limitations in predicting individual cardiovascular events, especially in young adults and women.
  • Endothelial dysfunction, an early sign of atherosclerosis, is linked to adverse cardiovascular outcomes like myocardial infarction, stroke, and death.
  • Personalized medicine trends emphasize individualized risk assessment using advanced screening tests.

Purpose of the Study:

  • To review the scientific basis and available methods for assessing endothelial function.
  • To discuss the interpretation of endothelial function test results.
  • To propose clinical guidelines for integrating endothelial function testing into practice.

Main Methods:

  • Literature review of scientific background on endothelial function.
  • Analysis of various functional and imaging screening tests for endothelial function assessment.
  • Evaluation of data interpretation and clinical application guidelines.

Main Results:

  • Endothelial function assessment offers a functional insight into cardiovascular risk factors.
  • Current methods provide a more individualized risk prediction compared to traditional scores.
  • Integration of these tests can enhance accuracy in identifying individuals at high cardiovascular risk.

Conclusions:

  • Endothelial function testing is a valuable tool for improving cardiovascular risk prediction.
  • Clinical guidelines are proposed for the practical application of these tests.
  • Adopting endothelial function assessment supports the shift towards personalized cardiovascular medicine.
Abstract

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