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Updated: Feb 13, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
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Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

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Complex Interaction of Hb Q-Thailand (HBA1: c.223G>C) with β-Thalassemia/Hb E (HBB: c.79G>A) Disease

Sitthichai Panyasai1, Surada Satthakarn1, Sakorn Pornprasert2

  • 1a Department of Medical Technology, Faculty of Allied Health Sciences , Phayao University , Phayao , Thailand.

Hemoglobin
|February 28, 2018
PubMed

Hb Q-Thailand [α74(EF3)Asp→His (α1), GAC>CAC, HBA1: c.223G>C] is an abnormal hemoglobin (Hb) frequently found in Thailand and Southeast Asian countries. The association of the αQ-Thailand allele with other globin gene disorders has important implications in diagnosis. Here, we report how to diagnose the coinheritance of Hb Q-Thailand with β-thalassemia (β-thal)/Hb E disease in four Thai samples from high performance liquid chromatography (HPLC) and capillary electrophoresis (CE) testing results. Understanding of the HPLC chromatogram and CE electropherogram patterns of this complex mutation is important for interpretation of testing results and providing genetic counseling.

Keywords:
Hb Q-Thailandcapillary electrophoresis (CE)hemoglobinopathyhigh performance liquid chromatography (HPLC)β-Thalassemia (β-thal)/Hb E

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