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Insulin resistance in hidradenitis suppurativa: a case-control study
I Vilanova1, J L Hernández2, C Mata3
1Division of Dermatology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria, Santander, Cantabria, Spain.
Journal of the European Academy of Dermatology and Venereology : JEADV
|February 28, 2018
Summary
Hidradenitis suppurativa (HS) patients have a significantly higher prevalence of insulin resistance (IR) compared to controls. Early evaluation and management of IR in HS patients are recommended.
Area of Science:
- Dermatology
- Endocrinology
- Metabolic Syndrome
Background:
- Chronic inflammatory diseases are linked to insulin resistance (IR).
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition.
Purpose of the Study:
- To determine the prevalence of insulin resistance (IR) in patients diagnosed with hidradenitis suppurativa (HS).
Main Methods:
- A cross-sectional, case-control study involving 137 participants (76 HS patients, 61 controls).
- Insulin resistance was assessed using the homeostasis model assessment of IR (HOMA-IR) calculated from fasting glucose and insulin levels.
- Demographic, clinical, anthropometric, and cardiovascular risk factor data were collected.
Main Results:
- HS patients exhibited a significantly higher median HOMA-IR value (2.0) compared to controls (1.5).
- The prevalence of IR was substantially higher in HS patients (43.4%) versus controls (16.4%).
- HS remained a significant independent factor for elevated HOMA-IR after adjusting for age, sex, and BMI.
Conclusions:
- This study demonstrates an increased frequency of insulin resistance (IR) in individuals with hidradenگان suppurativa (HS).
- Clinical guidelines should consider evaluating HS patients for IR and implementing appropriate management strategies.
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