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Cold air-induced rhinorrhea and high-dose ipratropium
Archives of Otolaryngology--Head & Neck Surgery
|February 1, 1987
Summary
A high dose of ipratropium bromide nasal spray significantly reduced rhinorrhea caused by cold air and hot soup. This suggests nasal discharge from these triggers is reflex-mediated and treatable with cholinoceptor antagonists.
Area of Science:
- Nasal Physiology
- Pharmacology
- Otolaryngology
Background:
- Rhinorrhea, or runny nose, can be triggered by various stimuli.
- The role of reflex-mediated hypersecretion from nasal glands in cold air and hot soup-induced rhinorrhea requires further elucidation.
Purpose of the Study:
- To investigate the extent to which cold air- and hot soup-induced rhinorrhea are reflex-mediated hypersecretions.
- To evaluate the efficacy of a cholinoceptor antagonist in managing these types of rhinorrhea.
Main Methods:
- A placebo-controlled study involving fourteen healthy volunteers.
- Administration of a single high dose (400 micrograms) of ipratropium bromide via nasal spray.
- Measurement of rhinorrhea reduction in response to cold air and hot soup stimuli.
Main Results:
- Ipratropium bromide resulted in a 73% reduction in cold air-induced rhinorrhea.
- A 66% reduction in hot soup-induced rhinorrhea was observed with ipratropium bromide.
- The drug was well-tolerated in the tested dose.
Conclusions:
- A significant portion of nasal discharge triggered by cold air and hot soup is mediated by reflexes.
- Cholinoceptor antagonists, such as ipratropium bromide, represent a viable therapeutic option for managing reflex-mediated rhinorrhea.