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Updated: Feb 13, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
Lipophilicity evaluation of some thiazolyl-1,3,4-oxadiazole derivatives with antifungal activity
Cristina Ioana Stoica1, Ioana Ionuț2, Laurian Vlase3
1Department of Therapeutical Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania.
Abstract:
The chromatographic behavior of a series of thiazolyl-1,3,4-oxadiazoles with antifungal activity was studied by reverse-phase thin-layer chromatography (RP-TLC). The lipophilicity parameters derived from RP-TLC were correlated with the data derived from liquid-chromatography mass-spectrometry. Good linear relationships were observed between the chromatographic lipophilicity parameters and the theoretical lipophilicity descriptors (logP) generated by various computer software and internet modules. Principal component analysis, applied on the experimental chromatographic lipophilicity indices and the theoretically calculated logP, enabled us to obtain a lipophilicity chart for better vizualization of the similarities and differences of the investigated compounds, which were grouped by k-means clustering in two congeneric classes.
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